"Calcium Signaling/drug effects"

Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.

The effects of ER stress on protein secretion by cardiac myocytes are not well understood. In this study, the ER stressor thapsigargin (TG), which depletes ER calcium, induced death of cultured neonatal rat ventricular myocytes (NRVMs) in high media …

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release.

BACKGROUND: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes …