Mark A. Sussman

Latest

• Peptidyl-Prolyl Isomerase 1 Regulates Ca(2+) Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na(2+)/Ca(2+) Exchanger 1 Protein Levels and Function.
• S100A4 protects the myocardium against ischemic stress.
• Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.
• PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
• Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
• Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
• Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.
• PHLPP-1 negatively regulates Akt activity and survival in the heart.
• Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.
• Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
• Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.
• Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
• Pim-1 regulates cardiomyocyte survival downstream of Akt.
• Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.
• Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.
• Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.