Donna J. Thuerauf

Latest

• Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation.
• The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
• Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
• Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
• ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
• Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
• ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
• Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release.
• S100A4 protects the myocardium against ischemic stress.
• Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.
• PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
• Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
• Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
• Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.
• Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death.
• Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
• Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response.
• Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
• Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
• The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
• Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.
• Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
• Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability.
• Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.
• Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
• MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo.
• Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis.
• Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.